منابع مشابه
Chromosome orientation
Precise chromosome segregation during cell division results from the attachment of chromosomes to microtubules emanating from both poles of the spindle apparatus. The molecular machinery involved in establishing and maintaining properly oriented microtubule attachments remains murky. Some clarity is now emerging with the identification of Bod1 (Biorientation Defective 1), a protein that promote...
متن کاملChromosome Bi-Orientation: Euclidian Euploidy
Establishment of proper attachments between chromosomes and microtubules is essential for the accurate division of the genome. Two recent studies indicate that these attachments are facilitated by the geometry of chromosomes and the bipolar arrangement of spindle microtubules.
متن کاملPOLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments.
Correct chromosome segregation during cell division requires bi-orientation at the mitotic spindle. Cells possess mechanisms to prevent and correct inappropriate chromosome attachment. Sister kinetochores assume a 'back-to-back' geometry on chromosomes that favors amphitelic orientation but the regulation of this process and molecular components are unknown. Abnormal chromosome-spindle interact...
متن کاملOrientation of genes in the Bacillus subtilis chromosome.
The orientation of 96 genes on the Bacillus subtilis chromosome was deduced by the analysis of published data. Of these genes, 91 were found to be oriented so that their promoters were proximal to the chromosomal replication origin and their transcription termini to the replication terminus. Transcription of these genes would therefore be co-directional with replication. This chromosomal organi...
متن کاملMerotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary cells.
Defects in chromosome segregation play a critical role in producing genomic instability and aneuploidy, which are associated with congenital diseases and carcinogenesis. We recently provided evidence from immunofluorescence and electron microscopy studies that merotelic kinetochore orientation is a major mechanism for lagging chromosomes during mitosis in PtK1 cells. Here we investigate whether...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200709152